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Active surveillance and pathological outcomes after RP

New data from a research group at the University of California provides insight regarding the immediate, relative, pathological outcomes of men undergoing radical prostatectomy (RP) after a period of...

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Clinical implications of an initial diagnosis of ASAP

Relatively few data have been published on the pathological outcomes of patients initially diagnosed with atypical small acinar proliferation (ASAP), i.e., atypical glands suspicious but not diagnostic...

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Pretreatment T level and post-surgical pathologic stage: a prognostic...

A new study by a French research team has suggested that there may be a prognostic relationship between the pretreatment testosterone (T) level and the post-surgical pathology of men who undergo...

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Does topography of cancer in the prostate correlate to risk for positive...

An interesting new report from the research team at Memorial Sloan-Kettering Cancer Center has explored the relationship between the patterns of occurrence of positive lymph nodes (LNs) and the...

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Should all “cribriform” prostate cancers be classified as Gleason 4 disease?

In recommendations made in association with a newly published study of the pathologiocal implications of “cribriform” prostate cancer tumors, Dr. Scott Lucia and colleagues are suggesting that all such...

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A new name for some forms of neoplastic prostate pathology?

The issue of whether to remove the “cancer” word from the diagnosis of at least some forms of prostate pathology that are not likely to lead to clinically significant disease over an extended period of...

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Do these data from Johns Hopkins really add to our knowledge base?

A somewhat surprising paper from Johns Hopkins appears (unsurprisingly) to confirm what the Kattan pre-treatment nomogram has been telling us for years … that higher Gleason scores, higher PSA levels,...

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Albertsen on the problems of screening and active surveillance

A paper just published in European Urology addresses pathologic outcomes among men initially managed with active surveillance and subsequently treated by deferred radical prostatectomy (RP). The paper...

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A real decrease in the use of RP in treatment of men with low-risk prostate...

A new paper from clinical research teams at two French hospitals suggests that there has been a significant relative increase (from 2005 to 2010, at their institutions) in the percentage of men found...

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Active surveillance and African Americans with very low-risk disease

A new study in the Journal of Clinical Oncology has suggested that African American men with very low-risk disease (according to the National Comprehensive Cancer Network or NCCN definition) are at...

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Increasing consensus on eligibility criteria for active surveillance

A paper in the journal Virchows Archiv suggests increasing consensus on both inclusion criteria for management on active surveillance and progression criteria suggesting the need for active treatment....

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Consensus statement on pathologic factors and active surveillance

As previously mentioned earlier this week, a long statement that deals with the role of the pathologist in determining the suitability of patients for enrollment into active surveillance management...

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Short-term outcomes after radical prostatectomy and surgeon training/practice...

Now here’s some data that may cause a bit of a furore … so before the US-based urologists get upset, we’d like to point out that this is a Canadian study based on data from members of the Canadian...

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Declining trend in the utilization of adjuvant radiation after surgery

A recent report in European Urology found that, in spite of three randomized clinical trials (RCTs) that proved the efficacy of immediate or adjuvant radiation following surgery with adverse pathology...

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Toward a new prostate cancer grading system — step 1

In the most recent issue of AUA News, Dr. Jonathon Epstein of  Johns Hopkins — unarguably one of the world’s leading prostate cancer pathologists — has laid out the general principles behind a new,...

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The biology and pathology of “young age” prostate cancer

A recent article in the Journal of Clinical Pathology reviews available data about the epidemiology, biology, and clinical pathology of “young age” prostate cancer, which the authors define as...

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Post-surgical pathology, active surveillance, and selection of appropriate...

An interesting — if unsurprising — new set of data in the Journal of Korean Medical Science has again shown that most of the current “standard” sets of criteria for selection of patients aren’t even...

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Are low serum levels of vitamin D a risk factor for aggressive forms of...

It has long between understood that there is an association between a man’s serum levels of vitamin D and his risk for prostate cancer in general and clinically significant prostate cancer in...

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A pathological “take” on the potential role of focal therapy

Various forms of focal therapy are now being used by some physicians to treat selected patients with well-identified, usually relatively small, “dominant” or “index” tumors that are confined to highly...

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Low volume, Gleason 3 + 4 = 7 disease: is active surveillance a realistic...

It would be easy to misinterpret (or at least “over-interpret”) a recent paper from the group at Johns Hopkins about the pathological outcomes of men initially diagnosed with very low-, low-, or...

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